Antidepressant

Details Antidepressant Antidepressant

A - Human Necessities

61

K

A61K 31/495 (2006.01) A61K 31/445 (2006.01) A61K 31/454 (2006.01) A61K 31/496 (2006.01) C07D 207/28 (2006.01)

Patent

CA 2168265

The invention provides an antidepressant composition which comprises, as an active ingredient, a pyroglutamide derivative of the general formula [I]: Image [ I ] wherein Y is CH2 or N-R (in which R is an alkoxycarbonyl group, a substituted or unsubstituted aralkyl group or a morpholinocarbonylalkyl group), or a pharmaceutically acceptable salt thereof. The compound of the invention is useful in the prevention or treatment of depressive state or depression.

La présente invention concerne un nouveau procédé énantio-spécifique de préparation d'acide (S)-4-amino-hepta-5,6-diénoïque et de sels pharmaceutiquement acceptables de celui-ci. Ces composés sont utiles comme inhibiteurs irréversibles du GABA-T. L'invention concerne également de nouveaux intermédiaires de ces composés, et leur procédé de préparation.

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