C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
167/216, 260/248
C07D 471/04 (2006.01) A61K 31/53 (2006.01)
Patent
CA 1267142
A B S T R A C T The invention relates to new compounds of the general Formula I Image /I/ and isomers thereof /wherein R1 is C1-10 alkyl, C3-6 cycloalkyl or phenyl, naphthyl or phenyl-/C1-4 alkyl/, wherein the aryl ring of the three latter groups may optionally bear one or more halogen, nitro, trifluoromethyl, amino, hydroxy, C1-4 alkyl and/or C1-4 alkoxy substituent/s/; R2 stands for hydrogen, halogen, hydroxy, oxo, C1-4 alkyl, C1-4 aloxy, phenyl or naphthyl, wherein the two latter groups may optionally bear one or more halogen, nitro, trifluoromethyl, amino, hydroxy, C1-4 alkyl and/or C1-4 alkoxy substituent/s/; R3 represents hydrogen, hydroxy or C1-4 alkoxy; Z is buta-1,3-dienyl or a group of the general Formula /a/ Image /a/ or /b/ Image /b/ and X is hydrogen or halogen. The compounds of the genreal Formula I posses useful pharmacological properties, particularly antidepressant and antiarrhythmial effect.
463562
Batori Sandor
Benko Pal
Grasser Katalin
Hajos Gyorgy
Messmer Andras
Batori Sandor
Benko Pal
Egyt Gyogyszervegyeszeti Gyar
Fetherstonhaugh & Co.
Grasser Katalin
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