Antidepressant derivatives of cis-4-phenyl-...

Details Antidepressant derivatives of cis-4-phenyl-... Antidepressant derivatives of cis-4-phenyl-...

C - Chemistry, Metallurgy

07

C

260/595.7

C07C 43/21 (2006.01) C07C 45/00 (2006.01) C07C 45/28 (2006.01) C07C 45/46 (2006.01) C07C 49/697 (2006.01) C07C 57/58 (2006.01) C07C 57/60 (2006.01)

Patent

CA 1130815

P.C. 6224 ANTIDEPRESSANT DERIVATIVES OF CIS-4-PHENYL-1,2,3,4- TETRAHYDRO-1-NAPHTHALENAMINE Abstract Novel cis-isomeric derivatives of 4-phenyl-1,2,3,4- tetrahydro-1-naphthalenamine are useful as antidepressant agents. These novel compounds act to block the synaptosomal uptake of serotonin (5-hydroxy-tryptamine), thereby alleviating serotonin abnormalities at central receptor sites. The preferred embodiment is the enantiomer cis-(1S)-N-methyl-4-(3,4-dichlorophenyl)- 1,2,3,4-tetrahydro-1-naphthalenamine and its pharmaceutically acceptable acid addition salts.

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