Antidepressant derivatives of trans-4-phenyl-...

Details Antidepressant derivatives of trans-4-phenyl-... Antidepressant derivatives of trans-4-phenyl-...

C - Chemistry, Metallurgy

07

C

260/595.7

C07C 43/21 (2006.01) C07C 45/00 (2006.01) C07C 45/46 (2006.01) C07C 49/697 (2006.01) C07C 49/755 (2006.01) C07C 57/58 (2006.01) C07C 57/60 (2006.01)

Patent

CA 1130816

P.C.(Ph) 6225A ANTIDEPRESSANT DERIVATIVES OF TRANS-4-PHENYL-1,2,3,4- TETRAHYDRO-1-NAPHTALENAMINE Abstract Novel trans-isomeric derivatives of 4-phenyl-1,2,3,4- tetrahydro-1-naphthalenamine are useful as antidepressant agents. These novel compounds act to block the synaptosomal uptake of norepinephrine and serotonin (5- hydroxy-tryptamine), thereby alleviating abnormalities at central receptor sites. The preferred embodiment is the enantiomer trans-(1R)-N-methyl-4-(3,4-dichlorophenyl)- 1,2,3,4-tetrahydo-1-naphthalenamine and its pharmaceutically acceptable acid addition salts.

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