Antidepressant n-substituted nicotinamide compounds

Details Antidepressant n-substituted nicotinamide compounds Antidepressant n-substituted nicotinamide compounds

C - Chemistry, Metallurgy

07

D

167/229, 260/278

C07D 213/56 (2006.01) A61K 31/455 (2006.01) C07D 213/82 (2006.01) C07D 401/12 (2006.01)

Patent

CA 1329605

ABSTRACT OF THE DISCLOSURE ANTIDEPRESSANT N-SUBSTITUTED NICOTINAMIDE COMPOUNDS Certain N-substituted nicotinamide compounds having formula (I) below Image (I) and pharmaceutically acceptable acid addition salts thereof wherein R1 is 1-piperidyl, 1-(3-indolyl)ethyl, C1-4 alkyl, phenyl, 1-(1-phenylethyl), benzyl or mono-substituted benzyl wherein the substituent is methyl, methoxy, chloro or fluoro; and R2 is bicyclo[2.2.1]hept-2-yl or Image wherein Y is hydrogen, fluoro or chloro; and X is hydrogen, fluoro, chloro, methoxy, trifluoromethyl, cyano, carboxy, carbo(C1-4 alkoxy), methylcarbamoyl or dimethylcarbamoyl function as selective inhibitors of calcium-independent phosphodiesterase and are useful as antidepressants.

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