Antidepressants

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/53 (2006.01) A61K 31/535 (2006.01) A61K 31/54 (2006.01) C07D 487/04 (2006.01)

Patent

CA 2148502

- 22 - ABSTRACT The present invention relates to an antidepressant containing as an active ingredient a triazine derivative or a pharmaceutically acceptable salt thereof, the derivative being represented by the following Formula (I): Image (I) in which, R1 represents hydrogen, substituted or unsubstituted lower alkyl, or substituted or unsubstituted lower alkanoyl; R2 represents hydrogen, substituted or unsubstituted lower alkyl, substituted or unsubstituted lower alkenyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted aryl, substituted or unsubstituted aralkyl, or a substituted or unsubstituted heterocyclic group; R3 represents a substituted or unsubstituted heterocyclic group; X represents a single bond, O, S, S(O), S(O)2 , or NR4 (in which R4 represents hydrogen, or substituted or unsubstituted lower alkyl; or R2 and NR4 are combined to form a substituted or unsubstituted 4 to 6-membered saturated heterocyclic group); and A represents N or CR5 (in which R5 represents hydrogen, or substituted or unsubstituted lower alkyl).

L'invention se rapporte à un antidépresseur qui contient comme principe actif un dérivé de triazine représenté par la formule générale (I) ou un sel pharmacologiquement acceptable de ce dérivé. Dans la formule (I), R<1> représente hydrogène, alkyle inférieur (non) substitué ou alcanoyle inférieur (non) substitué; R<2> représente hydrogène, alkyle inférieur (non) substitué, alcényle inférieur (non) substitué, cycloalkyle (non) substitué, aryle (non) substitué, aralkyle (non) substitué ou hétérocycle (non) substitué; R<3> représente hétérocycle (non) substitué; X représente une liaison simple, O, S, S(O), S(O)2 ou NR<4>, où R<4> représente hydrogène ou alkyle inférieur (non) substitué ou R<2> et NR<4> sont combinés l'un à l'autre pour former un groupe hétérocyclique saturé à l'azote (non) substitué à 4-6 éléments; et A représente N ou CR<5>, où R<5> représente hydrogène ou alkyle inférieur (non) substitué.

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