C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
167/208, 167/275
C07D 295/08 (2006.01) A61K 31/135 (2006.01) A61K 31/275 (2006.01) A61K 31/44 (2006.01) A61K 31/495 (2006.01) A61K 31/55 (2006.01) C07C 213/02 (2006.01) C07D 295/096 (2006.01)
Patent
CA 1327795
ABSTRACT The present invention provides novel compounds which are aryloxy indanamines of the formula: Image wherein R1 is a C1-C3 alkylene; n, p and q are 0, 1 or 2; Y and X are lower alkyl, lower alkoxy, hydroxy, CF3, halogeno; R2 and R3 are hydrogen, lower alkyl, aralkyl, or R2 and R3 taken together with the adjacent nitrogen are pyrrolidino, morpholino, piperidino, piperazino, or 4- methylpiperazino, or an acid addition salt thereof. They are useful as antidepressants and as inhibitors of synap- tic norepinephrine and serotonin uptake.
574102
Dudley Mark W.
Freedman Jules
Merrell Dow Pharmaceuticals (canada) Inc.
Osler Hoskin & Harcourt Llp
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