Antidiabetic bicyclic compounds

Details Antidiabetic bicyclic compounds Antidiabetic bicyclic compounds

C - Chemistry, Metallurgy

07

C

C07C 59/72 (2006.01) A61K 31/335 (2006.01) A61K 31/352 (2006.01) A61K 31/421 (2006.01) A61K 31/426 (2006.01) A61K 31/44 (2006.01) A61K 31/47 (2006.01) A61P 3/10 (2006.01) C07D 213/643 (2006.01) C07D 215/233 (2006.01) C07D 311/58 (2006.01) C07D 333/60 (2006.01) C07D 405/12 (2006.01)

Patent

CA 2667249

Diaryl ethers in which one of the aryl groups is a phenyl fused to a cycloalkyl or heterocyclic ring, to which is attached an acetic acid group, are agonists of G-protein coupled receptor 40 (GPR40) and are useful as therapeutic compounds, particularly in the treatment of Type 2 diabetes mellitus, and of conditions that often accompany this disease, including insulin resistance, obesity and lipid disorders.

L'invention porte sur des éthers diaryliques dans lesquels l'un des groupes aryle est un phényle fusionné à un cycloalkyle ou à un anneau hétérocyclique lié à groupe d'acide acétique. Lesdits éthers sont des agonistes du récepteur 40 couplé à la protéine G (GPR40) et sont des composés thérapeutiques, particulièrement utiles dans le traitement du diabète sucré de type 2 et des états souvent associés dont la résistance à l'insuline, l'obésité et les troubles lipidiques.

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