Antidiabetic bicyclic compounds

Details Antidiabetic bicyclic compounds Antidiabetic bicyclic compounds

C - Chemistry, Metallurgy

07

D

C07D 413/04 (2006.01) A61K 31/435 (2006.01) A61K 31/47 (2006.01) A61P 3/10 (2006.01) C07D 215/20 (2006.01) C07D 413/14 (2006.01) C07D 417/04 (2006.01) C07D 417/14 (2006.01)

Patent

CA 2593788

Bicyclic compounds containing a fused pyridine ring, including pharmaceutically acceptable salts and prodrugs thereof, are agonists of G- protein coupled receptor 40 (GPR40) and are useful as therapeutic compounds, particularly in the treatment of Type 2 diabetes mellitus, and of conditions that are often associated with this disease, including obesity and lipid disorders, such as mixed or diabetic dyslipidemia, hyperlipidemia, hypercholesterolemia, and hypertriglyceridemia.

L'invention concerne des composés bicycliques contenant un noyau pyridine fusionné, y compris les sels et promédicaments pharmaceutiquement acceptables de celui-ci, qui sont des agonistes du récepteur couplé aux protéines G 40 (GPR40) et qui sont utiles comme composés thérapeutiques, en particulier dans le traitement du diabète sucré de type 2, et d'états souvent associés à cette maladie, y compris l'obésité et les troubles lipidiques, tels que la dyslipidémie mixte ou diabétique, l'hyperlipidémie, l'hypercholestérolémie, et l'hypertriglycéridémie.

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