Antidiabetic bicyclic compounds

Details Antidiabetic bicyclic compounds Antidiabetic bicyclic compounds

C - Chemistry, Metallurgy

07

D

C07D 263/44 (2006.01) A61K 31/421 (2006.01) A61K 31/422 (2006.01) A61K 31/426 (2006.01) A61K 31/427 (2006.01) A61K 31/4439 (2006.01) A61K 31/4725 (2006.01) A61P 3/10 (2006.01) C07D 277/34 (2006.01) C07D 413/04 (2006.01) C07D 413/12 (2006.01) C07D 417/04 (2006.01) C07D 417/12 (2006.01)

Patent

CA 2593858

Bicyclic compounds containing a phenyl or pyridyl ring fused to a cycloalkyl or heterocyclic ring, to which is attached a 5-membered heterocyclic ring, including pharmaceutically acceptable salts and prodrugs thereof, are agonists of G-protein coupled receptor 40 (GPR40) and are useful as therapeutic compounds, particularly in the treatment of Type 2 diabetes mellitus, and of conditions that are often associated with this disease, including obesity and lipid disorders, such as mixed or diabetic dyslipidemia, hyperlipidemia, hypercholesterolemia, and hypertriglyceridemia.

La présente invention concerne des composés bicycliques contenant un cycle phényle ou pyridyle fusionné à un cycle cycloalkyle ou hétérocyclique, auquel est attaché un anneau hétérocyclique à 5 éléments, ainsi que leurs sels et promédicaments pharmaceutiquement acceptables. Ce sont des agonistes du récepteur 40 couplé à une protéine G (GPR40) et ils sont utilisés comme composés thérapeutiques, en particulier dans le traitement du diabète de type 2, et d~états souvent associés à cette maladie, comme l~obésité et les troubles lipidiques, tels que la dyslipidémie mixte ou diabétique, l'hyperlipidémie, l'hypercholestérolémie, et l~hypertriglycéridémie.

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