Antidiabetic compounds

Details Antidiabetic compounds Antidiabetic compounds

C - Chemistry, Metallurgy

07

K

C07K 14/605 (2006.01)

Patent

CA 2665033

The present invention provides novel peptidomimetics, of formula (I): A-Z1-Z2-Z3-Z4-Z5-Z6-Z7-Z8-Z9-Z10-Z11-B, which primarily act as glucose dependent insulin secretagogues. Furthermore, it was found that these peptidomimetics showed glucagon receptor antagonistic activity, along with the GLP-1 receptor agonistic activity.

L'invention porte sur de nouveaux composés peptidomimétiques, de formule (I), agissant principalement comme sécrétagogues de l'insuline dépendant du glucose. En outre, il a été trouvé que ces composés ont une activité antagoniste du récepteur du glucagon ainsi qu'une activité antagoniste du récepteur GLP-1.

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