Antidiabetic oxazolidinediones and thiazolidinediones

Details Antidiabetic oxazolidinediones and thiazolidinediones Antidiabetic oxazolidinediones and thiazolidinediones

C - Chemistry, Metallurgy

07

D

C07D 263/44 (2006.01) A61K 31/421 (2006.01) A61K 31/426 (2006.01) A61P 3/10 (2006.01) C07D 277/34 (2006.01)

Patent

CA 2553405

Phenoxyphenyl and phenoxybenzyl oxazolidine-2,4-diones and thiazolidine-2,4- diones of formula (I) are agonists or partial agonists of PPAR gamma and are useful in the treatment and control of hyperglycemia that is symptomatic of type II diabetes, as well as dyslipidemia, hyperlipidemia, hypercholesterolemia, hypertriglyceridemia, and obesity that are often associated with type 2 diabetes.

L'invention concerne des phénoxyphényl et phénoxybenzyl oxazolidine-2,4-diones et thiazolidine-2,4-diones représentées par la formule générale (I), utilisées comme agonistes ou agonistes partiels du récepteur PPAR gamma et destinées au traitement et au contrôle de l'hyperglycémie symptomatique du diabète non insulino-dépendant, ainsi que de la dyslipidémie, de l'hyperlipidémie, de l'hypercholestérolémie, de l'hypertriglycéridémie et de l'obésité qui sont souvent associées au diabète non insulino-dépendant.

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