Antidotes for factor xa inhibitors and methods of using the...

Details Antidotes for factor xa inhibitors and methods of using the... Antidotes for factor xa inhibitors and methods of using the...

A - Human Necessities

61

K

A61K 38/48 (2006.01) A61K 35/14 (2006.01) A61P 7/04 (2006.01)

Patent

CA 2743496

The present invention relates to antidotes of anticoagulants targeting factor Xa which antidotes are used in combi-nation with blood coagulating agents or other heparin antidotes to prevent or reduce bleeding in a subject. The antidotes described herein have reduced or no intrinsic coagulant activity. Disclosed herein are methods of stopping or preventing bleeding in a pa-tient that is or will be undergoing anticoagulant therapy with a factor Xa inhibitor.

La présente invention concerne des antidotes danticoagulants ciblant le facteur Xa, ces antidotes étant utilisés en combinaison avec des agents de coagulation sanguine ou dautres antidotes dhéparine pour prévenir ou réduire le saignement chez un sujet. Les antidotes présentement décrits ont une activité coagulante réduite ou nulle. La présente invention concerne en outre des procédés darrêt ou de prévention du saignement chez un patient qui suit ou va suivre une thérapie anticoagulante avec un inhibiteur de facteur Xa.

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