A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/517 (2006.01) A61K 47/34 (2006.01) A61K 47/40 (2006.01) A61P 35/00 (2006.01) C07D 239/95 (2006.01)
Patent
CA 2718330
The present invention provides pharmaceutical compositions comprising an antifolate compound. The composition exhibit improved bioavailability, and they particularly incorporate beneficial excipients that increase solubility and bioavailability, such as cyclodextrins or compounds formed of fatty acid esters of glycerol and polyethylene glycol esters. The pharmaceutical compositions are useful in the treatment of multiple conditions, including abnormal cell proliferation, inflammatory diseases, asthma, and arthritis.
La présente invention concerne des compositions pharmaceutiques comprenant un composé antifolique. Lesdites compositions montrent une biodisponibilité améliorée. Par ailleurs, elles incorporent en particulier des excipients bénéfiques qui augmentent la solubilité et la biodisponibilité, tels que des cyclodextrines ou des composés formés desters dacides gras de glycérol et desters de glycol polyéthylénique. Ces compositions pharmaceutiques sont utiles dans le traitement détats multiples, incluant la prolifération cellulaire anormale, les maladies inflammatoires, lasthme et larthrite.
Pimplaskar Harish K.
Roberts Michael J.
Chelsea Therapeutics Inc.
Smart & Biggar
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