C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 311/00 (2006.01) A61K 31/352 (2006.01) A61P 31/10 (2006.01) C07D 405/02 (2006.01)
Patent
CA 2700530
Novel derivatives of enfumafungin are disclosed herein, along with their, pharmaceutically acceptable salts, hydrates and prodrugs. Also disclosed are compositions comprising such compounds, methods of preparing such compounds and methods of using such compounds as antifungal agents and/or inhibitors of (1,3)-.beta.-D-glucan synthase. The disclosed compounds, their pharmaceutically acceptable salts, hydrates and prodrugs, as well as compositions comprising such compounds, salts, hydrates and prodrugs, are useful for treating and/or preventing fungal infections and associated diseases and conditions.
L'invention porte sur de nouveaux dérivés de l'enfumafungine, conjointement avec leurs sels, hydrates et promédicaments pharmaceutiquement acceptables. L'invention porte également sur des compositions comprenant de tels composés, sur des procédés de préparation de tels composés et sur des procédés d'utilisation de tels composés en tant qu'agents antifongiques et/ou inhibiteurs de la (1,3)-ß-D-glucane synthase. Les composés décrits, leurs sels, hydrates et promédicaments pharmaceutiquement acceptables, ainsi que des compositions comprenant de tels composés, sels, hydrates et promédicaments, sont utiles pour traiter et/ou prévenir des infections fongiques et des maladies et états associés.
Balkovec James M.
Bouffard Frances Aileen
Dimick Gray Sarah M.
Fan Weiming
Mamai Ahmed
Merck Sharp & Dohme Corp.
Scynexis Inc.
Smart & Biggar
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