Antifungal and antibacterial peptides

Details Antifungal and antibacterial peptides Antifungal and antibacterial peptides

C - Chemistry, Metallurgy

07

K

C07K 7/00 (2006.01) C07K 14/47 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2315250

Substantially pure peptides containing between 13 and 20 amino acids, inclusive, having the amino acid sequence: R1-R2-R3-R4-R5-R6-R7-R8-R9-R10-R11- R12-R13-R14-R15-R16-R17-R18-R19-R20-R21-R22-R23, where R1 is Asp or is absent; R2 is Ser or is absent; R3 is His or is absent; R4 is Ala; R5 is Lys, Gln, Arg, or another basic amino acid; R6 is Arg, Gln, Lys, or another basic amino acid; R7 is His, Phe, Tyr, Leu, or another hydrophobic amino acid; R8 is His, Phe, Tyr, Leu, or another hydrophobic amino acid; R9 is Gly, Lys, Arg, or another basic amino acid; R10 is Tyr; R11 is Lys, His, Phe, or another hydrophobic amino acid; R12 is Arg, Gln, Lys, or another basic amino acid; R13 is Lys, Gln, Arg, another basic amino acid, or is absent; R14 is Phe or is absent; R15 is His, Phe, Tyr, Leu, another hydrophobic amino acid, or is absent; R16 is Glu or is absent; R17 is Lys or is absent; R18 is His or is absent; R19 is His or is absent; R20 is Ser or is absent; R21 is His or is absent; R22 is Arg or is absent; and R23 is Gly or is absent; and where Gln cannot simultaneously occupy positions R5, R6, R12, and R13 of the amino acid sequence, as well as pharmaceutical compositions containing these peptides and methods for treating fungal and bacterial infections using these peptides, are disclosed.

L'invention concerne des peptides sensiblement purs contenant entre 13 et 20 acides aminés, y compris la séquence d'acides aminés: R1-R2-R3-R4-R5-R6-R7-R8-R9-R10-R11-R12-R13-R14-R15-R16-R17-R18-R19-R20-R21-R22-R23. Dans ladite séquence, R1 est Asp ou est absent; R2 est Ser ou est absent; R3 est His ou est absent; R4 est Ala; R5 est Lys, Gln, Arg, ou un autre acide aminé basique; R6 est Arg, Gln, Lys ou un autre acide aminé basique; R7 est His, Phe, Tyr, Leu, ou un autre acide aminé hydrophobe; R8 est His, Phe, Tyr, Leu, ou un autre acide aminé hydrophobe; R9 est Gly, Lys, Arg, ou un autre acide aminé basique; R10 est Tyr; R11 est Lys, His, Phe, ou un autre acide aminé hydrophobe; R12 est Arg, Gln, Lys, ou un autre acide aminé basique; R13 est Lys, Gln, Arg, un autre acide aminé basique, ou est absent; R14 est Phe ou est absent; R15 est His, Phe, tyr, Leu, un autre acide aminé hydrophobe, ou est absent; R16 est Glu ou est absent; R17 est Lys ou est absent; R18 est His ou est absent; R19 est His ou est absent; R20 est Ser ou est absent; R21 est His ou est absent; R22 est Arg ou est absent; et R23 est Gly ou est absent; et Gln ne peut occuper simultanément les positions R5, R6, R12 et R13 de la séquence d'acides aminés. L'invention concerne en outre des compositions pharmaceutiques contenant lesdits peptides et des procédés de traitement d'infections fongiques ou bactériennes au moyen desdits peptides.

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