Antifungal antibiotic bu-3608 complex

Details Antifungal antibiotic bu-3608 complex Antifungal antibiotic bu-3608 complex

C - Chemistry, Metallurgy

07

H

167/184, 260/208

C07H 15/252 (2006.01) A61K 31/70 (2006.01) C07H 15/244 (2006.01) C12P 19/56 (2006.01)

Patent

CA 1337907

Disclosed herein are N-alkyl derivatives of antibiotics BU-3608, BU-3608 B, C, D and E as well as the corresponding desxylosyl compounds. These novel compounds are useful as antifungal agents. They have the following structure: Image II wherein R1 is H, or R1 is methyl and the resulting alanyl is D-alanyl; R2 is H or .beta.-D-xylosyl; and Y is NR3R4 or +NR3R4R5 X-; wherein R3, R4 and R5 are the same or different C1-5alkyl; and X- is a chloride ion; or a pharmaceutically acceptable salt thereof.

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