Antifungal compositions with improved bioavailability

Details Antifungal compositions with improved bioavailability Antifungal compositions with improved bioavailability

A - Human Necessities

61

K

A61K 31/495 (2006.01) A61K 9/14 (2006.01) A61K 31/496 (2006.01)

Patent

CA 2240161

The present invention is concerned with novel pharmaceutical compositions of itraconazole which can be administered to a mammal suffering from a fungal infection, whereby a single such dosage form can be administered once daily, and in addition at any time of the day independently of the food taken in by said mammal. These novel compositions comprise particles obtainable by melt-extruding a mixture comprising itraconazole and an appropriate water-soluble polymer and subsequently milling said melt-extruded mixture.

L'invention concerne de nouvelles compositions pharmaceutiques d'itraconazole qui peuvent être administrées à un mammifère atteint de mycose. Une seule dose peut être administrée une seule fois par jour et, de plus, à n'importe quel moment de la journée, indépendamment de la prise alimentaire. Ces nouvelles compositions contiennent des particules obtenues par extrusion à l'état fondu d'un mélange comprenant de l'itraconazole et un polymère hydrosoluble approprié, puis par broyage dudit mélange extrudé à l'état fondu.

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