Antifungal compounds and methods of use

G - Physics – 01 – N

Patent

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G01N 33/569 (2006.01) C12Q 1/18 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2413753

The invention provides screening methods for detecting and identifying compounds that bind to fungal specific target proteins and nucleic acids, as well as compounds which, upon binding or otherwise interacting with the target protein, can inhibit fungal growth, a method of preventing or inhibiting fungal growth in culture, a method of preventing or inhibiting fungal growth in a mammal and a method of studying pathogenic mycetes using such nucleic acid and/or protein sequences. Particularly preferred is the inhibition of the fungus Candida albicans.

Cette invention concerne des méthodes de criblage utilisées pour détecter et identifier des composés qui se lient à des protéines cibles fongiques spécifiques et à des acides nucléiques, ainsi que des composés qui, après liaison ou autre interaction avec la protéine cible, peuvent inhiber la prolifération fongique chez un mammifère. L'invention concerne également une méthode de prévention ou d'inhibition de la prolifération fongique dans une culture, une méthode de prévention ou d'inhibition de la prolifération fongique chez un mammifère, et une méthode d'étude de mycètes pathogènes au moyen desdites séquences d'acide nucléique et/ou de protéines. Une méthode particulièrement préférée est celle qui inhibe le champignon Candida albicans.

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