C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/48 (2006.01) C12Q 1/18 (2006.01) C12Q 1/68 (2006.01) G01N 33/569 (2006.01) G01N 33/573 (2006.01)
Patent
CA 2232536
The present invention relates to an antifungal in vitro and in vivo screening assays for identifying a compound which inhibit mannosyltransferase involved in protein O- and N-glycosylation. The antifungal screening assay for identifying a compound which inhibit mannosyltransferases involved in protein O- and N-glycosylation, comprises the steps of: a) subjecting proteins to specific mannosyltransferase protein encoded by a Saccharomyces cerevisiae mannosyltransferase encoding gene, wherein said gene is selected from the group consisting of KRE2/MNT1, YUR1, KTR1, KTR2, KTR3, KTR4, KTR5, KTR6 and KTR7; b) subjecting step a) to a screened compound and determining absence or presence of protein O- and N-glycosylation, wherein absence of protein O- and N-glycosylation is indicative of an antifungal compound. There is also disclosed an in vitro method for the diagnosis of diseases caused by fungal infection in a patient.
Bussey Howard
Lussier Marc
Sdicu Anne-Marie
Bussey Howard
Lussier Marc
Sdicu Anne-Marie
Swabey Ogilvy Renault
University Mcgill
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