Antifungal enediynes

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 307/54 (2006.01) A01N 43/08 (2006.01) A01N 43/10 (2006.01) A01N 43/36 (2006.01) A01P 3/00 (2006.01) A61K 31/341 (2006.01) A61K 31/381 (2006.01) A61K 31/40 (2006.01) A61P 31/10 (2006.01) C07D 207/337 (2006.01) C07D 333/24 (2006.01)

Patent

CA 2386514

The invention features enediynes and methods for their production and use. The enediynes of the invention have the formula (I) wherein R1 is a hydroxyl group or a moiety that can be replaced by a hydroxyl group in a hydrolysis reaction; each R2 is, independently, H or a monovalent hydrocarbon moiety containing between 1 and 4 carbon atoms, inclusive; R3 is a pyrrole, furan, or thiophene ring; and X is an integer between 4 and 10, inclusive.

L'invention concerne des ènediynes, ainsi que leurs procédés de production et d'utilisation. Les ènediynes selon l'invention sont représentées par la formule (I) dans laquelle R¿1? désigne un groupe hydroxyle ou une fraction pouvant être remplacée par un groupe hydroxyle dans une réaction d'hydrolyse ; chaque R¿2? désigne, indépendamment, H ou une fraction hydrocarbure monovalente contenant de 1 à 4 inclus atomes de carbone ; R¿3? désigne un cycle pyrrolle, furanne ou thiophène ; et X désigne un entier compris entre 4 et 10 inclus.

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