C - Chemistry – Metallurgy – 12 – P
Patent
C - Chemistry, Metallurgy
12
P
C12P 19/44 (2006.01) A01N 43/16 (2006.01) C07H 13/06 (2006.01) C07H 13/08 (2006.01) C07H 15/10 (2006.01) C12P 7/62 (2006.01)
Patent
CA 2208019
Novel antifungal agents having formula (I), wherein R is hydrogen or -C(O)-R1 wherein R1 is alkenyl, C2-C12-alkyl, aryl, arylalkenyl, arylalkyl, aryl-aryl-, arylalkoxy-aryl-, aryloxyl-aryl-, aryl-aryl-aryl- or arylalkoxy-aryl-aryl-, or pharmaceutically acceptable salts, esters or prodrugs thereof, as well as (i) pharmaceutical compositions comprising such compounds, (ii) methods of treatment using such compounds, and (iv) methods and fungal cultures useful in making the same.
L'invention se rapporte à de nouveaux agents antifongiques de formule (I) dans laquelle R représente hydrogène ou -C(O)-R¿1? où R¿1? représente alcényle, alkyle C¿2?-C¿12?, aryle, arylalcényle, arylalkyle, aryle-aryle-, arylalcoxy-aryle-, aryloxyle-aryle, aryle-aryle-aryle- ou arylalcoxy-aryle-aryle-, ou à des sels pharmaceutiquement acceptables, des esters ou des promédicaments de ceux-ci, ainsi qu'à (i) des compositions pharmaceutiques comprenant ces composés, (ii) des procédés de traitement de ces composés, et (iv) des procédés et des cultures fongiques utilisés dans leur fabrication.
Alder Lisa A.
Burres Neal S.
Hochlowski Jill E.
Jackson Marianna
Klein Larry L.
Abbott Laboratories
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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