Antifungal ketoconazole composition for topical use

Details Antifungal ketoconazole composition for topical use Antifungal ketoconazole composition for topical use

A - Human Necessities

61

K

A61K 47/10 (2006.01) A61K 31/496 (2006.01) A61K 47/14 (2006.01) A61P 17/08 (2006.01) A61P 31/10 (2006.01)

Patent

CA 2418008

A pharmaceutical composition suitable for topical application comprising ketoconazole in a solution which comprises: (i) 13 to 50 wt% water; (ii) 45 to 85 wt% of an alcohol having a boiling point of less than 100~C; and (iii) 2 to 30 wt% of a non-volatile, water miscible, non-ionic surface active agent; the ketoconazole being present in an amount of 0.5 to 3 wt% relative to components (i), (ii) and (iii).

Cette composition pharmaceutique, conçue pour une application topique, comprend du kétoconazole placé dans une solution composée de: (i) 13 à 50 % en poids d'eau, (ii) 45 à 85 % en poids d'un alcool dont le point d'ébullition est inférieur à 100 ·C, et (iii) 2 à 30 % en poids d'un agent tensioactif, non ionique, miscible dans l'eau, non volatil, la dose de kétoconazole présente dans la composition représentant 0,5 à 3 % du poids des composants (i), (ii), et (iii).

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