Antifungal nail coat and method of use

Details Antifungal nail coat and method of use Antifungal nail coat and method of use

A - Human Necessities

61

K

A61K 31/137 (2006.01) A61K 31/045 (2006.01) A61K 31/131 (2006.01) A61P 31/10 (2006.01)

Patent

CA 2519705

A dual action antifungal nail coat composition and method of use for ameliorating or preventing fungal infection of the nails, and onychomycosis, in particular, is disclosed. Composition embodiments in the form of one-coat type and two-coat type suitable for daily fungicidal regimens are disclosed. A preferred antifungal nail coat composition comprises an effective fungicidal amount of antifungal agent, a permeation enhancing amount of a substantially non-volatile, permeation enhancer, a film-forming amount of a hydrophilic polymer, and a pharmaceutically acceptable, volatile carrier. The composition provides a substantially water-soluble fungicidal coating on contacting a fungally susceptible or infected nail.

L'invention concerne une composition d'enduit à ongles antifongique à double effet et un procédé d'utilisation afin d'améliorer ou d'empêcher une infection fongique des ongles et en particulier onychomycose. L'invention concerne en outre des compositions de type monocouche et double couche convenables pour des applications quotidiennes fongicides. Une composition d'enduit à ongles antifongique préférée contient une quantité efficace de fongicide, une quantité d'un promoteur de perméation sensiblement non volatil, une quantité d'un polymère hydrophile, formant une couche, et un support volatile pharmaceutiquement acceptable. Cette composition fournit un enduit fongicide sensiblement soluble dans l'eau après mise en contact avec une ongle susceptible d'infections fongiques ou ayant une infection fongique.

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