C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/32 (2006.01) C07D 239/72 (2006.01) C12N 9/02 (2006.01) A61P 31/10 (2006.01)
Patent
CA 2721959
A method of identifying an antifungal agent which targets a DHODH protein (alias PyrE, dihydroorotate dehydrogenase, EC: 1.3.99.11) of a fungus comprising contacting a candidate substance with a fungal DHODH protein and determining whether the candidate substance binds or modulates the DHODH protein, wherein binding or modulation indicates that the candidate substance is an antifungal agent. Specific examples concern Aspergillus fumigatus and Candida albicans DHODH proteins. DHODH inhibitors with a Quinazolinone core are also disclosed.
L'invention porte sur un procédé d'identification d'un agent antifongique ciblant une protéine DHODH d'un champignon. Le procédé consiste à mettre en contact une substance candidate et une protéine DHODH fongique; et à déterminer si la substance candidate fixe ou module la protéine DHODH, identifiant ainsi la substance candidate comme agent antifongique.
Birch Michael
Bromley Michael John
Oliver Jason David
Sibley Graham Edward Morris
Thain John Leslie
F2g Limited
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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