Antigen-binding constructs

Details Antigen-binding constructs Antigen-binding constructs

C - Chemistry, Metallurgy

07

K

C07K 16/24 (2006.01) C07K 16/28 (2006.01) C07K 16/46 (2006.01)

Patent

CA 2753287

The invention relates to combinations of RANKL antagonists with TNF-alpha antagonists and provides antigen-binding constructs which bind to RANKL comprising a protein scaffold which are linked to one or more epitope-binding domains wherein the antigen-binding construct has at least two antigen binding sites at least one of which is from an epitope binding domain and at least one of which is from a paired VH/VL domain, methods of making such constructs and uses thereof.

L'invention concerne des combinaisons d'antagonistes de RANKL avec des antagonistes de TNF-alpha et concerne des constructions de liaison d'antigène qui se lient à RANKL comprenant un échafaudage protéique qui sont liées à un ou plusieurs domaines de liaison d'épitope où la construction de liaison d'antigène a au moins deux sites de liaison d'antigène dont au moins un est d'un domaine de liaison d'épitope et dont au moins un est d'un domaine VH/VL apparié, des procédés de préparation de telles constructions et des utilisations de celles-ci.

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