C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/46 (2006.01) A61K 39/395 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01) C07K 16/22 (2006.01) C07K 16/24 (2006.01) C07K 16/28 (2006.01) C07K 16/32 (2006.01) C12N 5/10 (2006.01) C12N 15/13 (2006.01)
Patent
CA 2706419
The invention relates to antigen-binding constructs comprising a protein scaffold which are linked to one or more epitope-binding domains wherein the antigen- binding construct has at least two antigen binding sites at least one of which is from an epitope binding domain and at least one of which is from a paired VH/VL domain, methods of making such constructs and uses thereof.
L'invention porte sur des produits de construction de liaison à un antigène comprenant un échafaudage de protéine, lesquels sont liés à un ou plusieurs domaines de liaison à un épitope, le produit de construction de liaison à un antigène ayant au moins deux sites de liaison d'antigène dont au moins l'un provient d'un domaine de liaison à un épitope et au moins l'un provient d'un domaine VH/VL apparié. L'invention porte également sur des procédés de fabrication de tels produits de construction et sur leurs utilisations.
Ashman Claire
Batuwangala Thil
Burden Michael Neil
Clegg Stephanie Jane
de Wildt Rudolf Maria
Glaxo Group Limited
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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