Antigen-binding molecule capable of binding to two or more...

Details Antigen-binding molecule capable of binding to two or more... Antigen-binding molecule capable of binding to two or more...

C - Chemistry, Metallurgy

07

K

C07K 16/28 (2006.01) A61K 39/395 (2006.01) C12P 21/08 (2006.01) G01N 33/15 (2006.01) G01N 33/50 (2006.01)

Patent

CA 2721052

The present inventors discovered that antibodies having weaker antigen-binding activity at the early endosomal pH in comparison with that at the pH of plasma are capable of binding to multiple antigen molecules with a single antibody molecule, have long half- lives in plasma, and have improved durations of time in which they can bind to antigen.

L'invention concerne une molécule d'un anticorps qui présente une activité de liaison à l'antigène plus faible à une valeur de pH dans un endosome précoce en comparaison de celle à une valeur de pH dans un plasma, ladite molécule pouvant se lier à deux molécules d'antigène ou plus. Selon l'invention, l'anticorps a une demi-vie longue dans un plasma et la durée pendant laquelle l'anticorps peut se lier à un antigène est améliorée.

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