C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/13 (2006.01) A61K 39/395 (2006.01) A61P 35/00 (2006.01) C07K 16/30 (2006.01) C07K 16/46 (2006.01) C07K 19/00 (2006.01) C12N 5/10 (2006.01) C12N 15/62 (2006.01) C12N 15/85 (2006.01) G01N 33/574 (2006.01) G01N 33/577 (2006.01)
Patent
CA 2601858
The present invention relates to antigen binding molecules (ABMs). In particular embodiments, the present invention relates to recombinant monoclonal antibodies, including chimeric, primatized or humanized antibodies specific for human MCSP. In addition, the present invention relates to nucleic acid molecules encoding such ABMs, and vectors and host cells comprising such nucleic acid molecules. The invention further relates to methods for producing the ABMs of the invention, and to methods of using these ABMs in treatment of disease. In addition, the present invention relates to ABMs with modified glycosylation having improved therapeutic properties, including antibodies with increased Fc receptor binding and increased effector function.
Molécules de liaison d'antigène et, sous des variantes spécifiques, anticorps monoclonaux de recombinaison, y compris anticorps chimères, primatisés ou humanisés spécifiques au protéoglycane chondroïtine sulfate du mélanome (MCSP). Par ailleurs, molécules d'acides nucléiques codant ces molécules de liaison d'antigène, et vecteurs et cellules hôtes renfermant les molécules d'acides nucléiques en question. Procédés de production des molécules de liaison considérées, et procédés relatifs à leur utilisation pour le traitement de maladies. Enfin, molécules de liaison d'antigène à glycosylation modifiée ayant des propriétés thérapeutiques améliorées, y compris les anticorps à fonction améliorée de liaison au récepteur Fc et effectrice.
Moessner Ekkehard
Umana Pablo
Glycart Biotechnology Ag
Gowling Lafleur Henderson Llp
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