C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/13 (2006.01) A61K 39/395 (2006.01) A61P 35/00 (2006.01) C07K 16/18 (2006.01) C07K 16/28 (2006.01) C07K 16/46 (2006.01) C07K 19/00 (2006.01) C12N 15/62 (2006.01) C12N 15/63 (2006.01) C12P 21/08 (2006.01) C07K 14/705 (2006.01)
Patent
CA 2605781
The present invention is directed to antigen binding molecules, including antibodies, comprising a Fc region having one or more amino acid modifications, wherein the antigen binding molecule exhibits altered binding to one or more Fc receptors as a result of the modification(s). The invention is further directed to polynucleotides and vectors encoding such antigen binding molecules, to host cells comprising the same, to methods for making the antigen binding molecules of the invention, and to their use in the treatment of various diseases and disorders, e.g., cancers.
L'invention concerne des molécules de liaison à l'antigène, notamment des anticorps, contenant une zone Fc possédant une ou plusieurs modifications amino-acides, la molécule de liaison à l'antigène présentant une liaison altérée à un ou plusieurs récepteurs Fc du fait de la/des modification(s). L'invention concerne en outre des polynucléotides et des vecteurs codant ces molécules de liaison à l'antigène, des cellule hôtes les contenant, des procédés destinés à fabriquer des molécules de liaison à l'antigène de l'invention, et leur utilisation dans le traitement de diverses maladies et troubles, par exemple, les cancers.
Brunker Peter
Ferrara Koller Claudia
Sondermann Peter
Stuart Fiona
Umana Pablo
Glycart Biotechnology Ag
Gowling Lafleur Henderson Llp
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