C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/24 (2006.01) A61K 39/395 (2006.01)
Patent
CA 2698382
The present disclosure provides compositions and methods relating to antigen binding proteins which bind to human thymic stromal lymphopoietin (TSLP), including antibodies. In particular embodiments, the disclosure provides fully human, humanized and chimeric anti-TSLP antibodies and derivatives of such antibodies. The disclosure further provides nucleic acids encoding such antibodies and antibody fragments and derivatives, and methods of making and using such antibodies including methods of treating and preventing TSLP-related inflammatory and fibrotic disorders.
La présente invention concerne des compositions et des procédés associés aux protéines de liaison à l'antigène qui se lient à la lymphopoïétine stromale thymique (TSLP), y compris les anticorps. Selon des modes de réalisation particuliers, l'invention concerne des anticorps complètement humains, humanisés et chimères anti-TSLP et des dérivés de tels anticorps. L'invention concerne également des acides nucléiques qui codent pour de tels anticorps, fragments d'anticorps et dérivés, ainsi que des procédés de préparation et d'utilisation de tels anticorps, notamment des procédés de traitement et de prévention de troubles fibrotiques et inflammatoires associés à la TSLP.
Comeau Michael R.
Mehlin Christopher
Smothers James F.
Yoon Bo-Rin P.
Amgen Inc.
Smart & Biggar
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