Antigen-binding proteins comprising a linker which confers...

Details Antigen-binding proteins comprising a linker which confers... Antigen-binding proteins comprising a linker which confers...

C - Chemistry, Metallurgy

12

N

C12N 15/11 (2006.01) C07K 16/46 (2006.01) C07K 19/00 (2006.01) C12N 1/19 (2006.01) C12N 15/81 (2006.01)

Patent

CA 2348839

Use of a polypeptide linker group, the amino acid sequence of which group confers restricted conformational flexibility, as a linking group to link binding units, preferably antigen binding units comprising heavy chain variable domains derived from an immunoglobulin naturally devoid of light chains, in a multivalent binding protein.

Cette invention a trait à l'utilisation d'un groupe liant polypeptidique, dont la séquence d'acides aminés confère une souplesse de conformation restreinte, comme groupe de fixation fixant des unités de fixation, de préférence des unités fixant un antigène comportant des domaines variables à chaîne lourde dérivée d'une immunoglobuline naturellement dépourvue de chaînes légères, dans une protéine de fixation polyvalente.

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