Antigen binding proteins that bind par-2

Details Antigen binding proteins that bind par-2 Antigen binding proteins that bind par-2

C - Chemistry, Metallurgy

07

K

C07K 16/28 (2006.01) C12N 15/13 (2006.01) C12P 21/08 (2006.01)

Patent

CA 2690538

The present invention provides compositions and methods relating to or derived from anti-PAR-2 antibodies. In particular embodiments, the invention provides human antibodies that bind PAR- 2, PAR-2-binding fragments and derivatives of such antibodies, and PAR-2-binding polypeptides comprising such fragments. Other embodiments provide nucleic acids encoding such antibodies, antibody fragments and derivatives and polypeptides, cells comprising such polynucleotides, methods of making such antibodies, antibody fragments and derivatives and polypeptides, and methods of using such antibodies, antibody fragments and derivatives and polypeptides, including methods of treating or diagnosing subjects having PAR-2-related disorders or conditions.

La présente invention porte sur des compositions et des procédés se rapportant à ou provenant d'anticorps anti-PAR-2. Dans des modes de réalisation particuliers, l'invention concerne des anticorps humains qui se lient à PAR-2, des fragments et dérivés de liaison à PAR-2 de tels anticorps, et des polypeptides de liaison à PAR-2 comprenant de tels fragments. D'autres modes de réalisation concernent des acides nucléiques codant pour de tels anticorps, fragments et dérivés d'anticorps et polypeptides, des cellules comprenant de tels polynucléotides, sur des procédés de fabrication de tels anticorps, fragments et dérivés d'anticorps et polypeptides, des procédés d'utilisation de tels anticorps, fragments et dérivés d'anticorps et polypeptides, comprenant des procédés de traitement ou de diagnostic de sujets ayant des troubles ou états apparentés à PAR-2.

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