Antigen binding proteins to proprotein convertase subtilisin...

Details Antigen binding proteins to proprotein convertase subtilisin... Antigen binding proteins to proprotein convertase subtilisin...

C - Chemistry, Metallurgy

07

K

C07K 16/40 (2006.01) A61K 39/395 (2006.01) A61P 3/06 (2006.01)

Patent

CA 2696252

Antigen binding proteins that interact with Proprotein Convertase Subtilisin Kexin Type 9 (PCSK9) are described. Methods of treating hypercholesterolemia and other disorders by administering a pharmaceutically effective amount of an antigen binding protein to PCSK9 are described. Methods of detecting the amount of PCSK9 in a sample using an antigen binding protein to PCSK9 are described.

L'invention concerne des protéines de liaison à un antigène qui interagissent avec la proprotéine convertase subtilisine kexine de type 9 (PCSK9). Des méthodes de traitement de l'hypercholestérolémie et d'autres troubles par l'administration d'une quantité efficace du point de vue pharmaceutique d'une protéine de liaison à un antigène pour PCSK9 sont décrits. Des procédés de détection de la quantité de PCSK9 dans un échantillon dans lesquels on utilise une protéine de liaison à un antigène pour PCSK9 sont décrits.

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