Antigen conjugates and uses thereof

Details Antigen conjugates and uses thereof Antigen conjugates and uses thereof

A - Human Necessities

61

K

A61K 39/12 (2006.01) C12N 15/12 (2006.01) C12N 15/48 (2006.01) C12N 15/52 (2006.01)

Patent

CA 2612069

The present invention is in the fields of medicine, public health, immunology, molecular biology and virology. The invention provides composition comprising a virus-like particle (VLP) linked to at least one antigen of the invention, wherein said antigen of the invention is CCR5 of the invention, gastrin of the invention, CXCR4 of the invention, CETP of the invention or C5a of the invention. The invention also provides a process for producing the composition. The compositions of this invention are useful in the production of vaccines, in particular, for the treatment of diseases in which the antigen of the invention mediates, or contributes to the condition, particularly for the treatment of AIDS, gastrointestinal cancers, coronary heart diseases or inflammatory diseases. Moreover, the compositions of the invention induce efficient immune responses, in particular antibody responses. Furthermore, the compositions of the invention are particularly useful to efficiently induce self-specific immune responses within the indicated context.

La présente invention, qui touche aux domaines de la médecine, de la santé publique de l'immunologie, de la biologie moléculaire et de la virologie, porte sur une composition comprenant une particule de type virus liée à au moins un antigène de l'invention pouvant être un CCR5 de l'invention, une gastrine de l'invention, un CXCR4 de l'invention, un CETP de l'invention, ou un C5a de l'invention. L'invention porte également sur le procédé de production de la composition. Les compositions de l'invention s'avèrent utiles pour la production de vaccins, en particulier pour le traitement de maladies où l'antigène de l'invention intervient ou contribue à l'état, et en particulier pour le traitement du SIDA, des cancers gastro-intestinaux, des maladies des coronaires ou des maladies inflammatoires. De plus, les compositions de l'invention suscitent d'efficaces réponses immunitaires, et en particulier des réponses par anticorps. En outre elles s'avèrent en particulier utiles pour susciter d'efficaces réponses immunitaires autospécifiques dans le contexte indiqué.

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