Antigen delivery system comprising monoglyceride or...

A - Human Necessities – 61 – K

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A61K 39/39 (2006.01) A61K 9/00 (2006.01) A61K 9/107 (2006.01) A61K 47/14 (2006.01)

Patent

CA 2295237

Adjuvants for administration, particularly for mucosal administration, of an antigen, are described, as well as compositions comprising the described adjuvant in combination with an antigen and a physiologically acceptable vehicle. Methods of eliciting and enhancing an immune response utilizing the adjuvant compositions of the invention are also described. The adjuvant comprises mono- or diglycerides containing at least one water soluble polymer, e.g. poly oxyethylene (PEG2-30). The antigen can be bound to the adjuvant. The adjuvant may be used in the treatment of plants as well.

Cette invention, qui a trait à des adjuvants pour l'administration d'antigène, par la voie des muqueuses notamment, ainsi qu'à des compositions les contenant, en association avec un antigène et un excipient physiologiquement acceptable, porte également sur des techniques d'élicitation et de renforcement de la réaction immunologique faisant intervenir les compositions d'adjuvants susmentionnées. L'adjuvant comprend des monoglycérides ou des diglycérides contenant au moins un polymère hydrosoluble, par exemple du polyoxyéthylène (PEG¿2-30?). L'antigène peut être lié à l'adjuvant. L'adjuvant peut aussi être utilisé dans le traitement de plantes.

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