Antigen mimotopes and vaccine against cancerous diseases

Details Antigen mimotopes and vaccine against cancerous diseases Antigen mimotopes and vaccine against cancerous diseases

A - Human Necessities

61

K

A61K 39/00 (2006.01) A61K 39/385 (2006.01) A61P 35/00 (2006.01) C07K 7/06 (2006.01)

Patent

CA 2458538

The invention relates to a vaccine against cancers and to antigen mimotopes that are associated with the high molecular weight melanoma associated antigen (HMW-MAA). The vaccine and antigen mimotopes are immunologically detected by the monoclonal HMW-MAA 225.28S antibody and comprise at least one peptide having a length of 6 to 14 amino acids. The inventive vaccine allows for an active immunization against cancers that are associated with the high molecular weight melanoma associated antigen (HMW-MAA) and has both prophylactic and therapeutical effects. The antigen mimotopes can also be used for an assay of the immune response achieved.

L'invention concerne un vaccin contre des affections cancéreuses, ainsi que des mimotopes d'antigène qui sont associés à l'antigène associé à un mélanome de poids moléculaire élevé (HMW-MAA). A cet effet, le vaccin et les mimotopes d'antigène sont détectés immunologiquement par l'anticorps HMW-MAA monoclonal 225.28S et comprennent au moins un peptide ayant une longueur comprise entre 6 et 14 acides aminés. Le vaccin selon l'invention permet une immunisation active contre des affections cancéreuses associées à l'antigène HMW-MAA, une action prophylactique aussi bien que thérapeutique pouvant être obtenue. En outre, les mimotopes d'antigène peuvent servir à la mise en évidence de la réponse immunitaire atteinte.

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