Antigen-presenting capsid with fusion ms2-coat protein

Details Antigen-presenting capsid with fusion ms2-coat protein Antigen-presenting capsid with fusion ms2-coat protein

C - Chemistry, Metallurgy

12

N

C12N 15/62 (2006.01) A61K 39/21 (2006.01) A61K 39/295 (2006.01) A61K 39/385 (2006.01) C07K 14/005 (2006.01) C07K 14/08 (2006.01) C07K 14/11 (2006.01) C07K 14/16 (2006.01) C07K 16/00 (2006.01) C07K 19/00 (2006.01) C12N 1/21 (2006.01) C12N 15/10 (2006.01) C12N 15/33 (2006.01) C12N 15/70 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2101070

A chimaeric protein, suitable for incorporation in a vaccine and capable of forming parts of a capsid assembly, comprises the amino acid sequence of the coat protein of phage MS-2, or a conservatively modified variant thereof, or sufficient of said sequence or variant to retain capsid-forming capability, which amino acid se- quence has been modified by insertion of a foreign epitope in the region correspond- ing to a protuberant protein hairpin in the capsid assembly as shown in the crystal structure of the intact phage.

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