C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 19/00 (2006.01) A61K 39/12 (2006.01) A61K 39/395 (2006.01) C07K 16/08 (2006.01) C12N 15/62 (2006.01) C12N 15/63 (2006.01)
Patent
CA 2754743
The present invention includes compositions and methods for the expression, secretion and use of novel compositions for use as, e.g., vaccines and antigen delivery vectors, to delivery antigens to antigen presenting cells. In one embodiment, the vector is an anti-CD40 antibody, or fragments thereof, and one or more antigenic peptides linked to the anti-CD40 antibody or fragments thereof, including humanized antibodies.
La présente invention porte sur des compositions et des procédés pour l'expression, la sécrétion et l'utilisation de nouvelles compositions aux fins d'une utilisation, par exemple, en tant que vaccins et vecteurs de distribution d'antigènes, de distribution des antigènes à des cellules présentant des antigènes. Dans un mode de réalisation, le vecteur est un anticorps anti-CD40, ou des fragments de celui-ci, et un ou plusieurs peptides antigéniques liés à l'anticorps anti-CD40 ou à des fragments de celui-ci, comprenant des anticorps humanisés.
Banchereau Jacques F.
Flamar Anne-Laure
Levy Yves
Montes Monica
Zurawski Gerard
Baylor Research Institute
Shapiro Cohen
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