Antigen-protein complex for blocking allergic reactions

C - Chemistry – Metallurgy – 08 – G

Patent

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530/5.08, 530/15

C08G 69/36 (2006.01) A61K 39/36 (2006.01) C07D 311/30 (2006.01) C07H 17/07 (2006.01) A61K 38/11 (2006.01)

Patent

CA 1099258

ANTIGEN-PROTEIN COMPLEX FOR BLOCKING ALLERGIC REACTIONS ABSTRACT OF THE DISCLOSURE A multivalent complex suitable for blocking allergic reactions comprising (1) at least one Timothy antigen D frag- ment having the antigenic determinant structure: Image wherein: G represents glucose, and T represents threonine or a peptide linked to said structure through a threonine molecule; covalently bonded through at least one glucose moiety to a peptide or protein, (2) a conjugate having the structure: Image or (3) a conjugate comprising at least one conjugate of the structure: Image covalently bonded to a protein or peptide by a peptide linkage through the glutathione moiety. A method of forming complex (1) by activating a glucose moiety of the Timothy antigen D fragment and reacting the thus activated intermediate with a peptide or protein. A method of treating allergies comprising in- jecting one of the above complexes into an individual to inhibit antigen-induced histamine release. An injectable composition for blocking allergic reactions containing the above complex.

288312

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