Antigen-specific cells, methods of generating these cells...

C - Chemistry – Metallurgy – 12 – Q

Patent

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C12Q 1/68 (2006.01) C07H 21/04 (2006.01) C12N 5/10 (2006.01) C12N 15/10 (2006.01) C12N 15/11 (2006.01) C12P 19/34 (2006.01) C12P 21/00 (2006.01)

Patent

CA 2318979

The present invention provides methods for identifying antigens recognized by immune effector cells. In one embodiment, the methods combine identifying amino acid sequence motifs of such antigens and the DNA sequences that potentially encode the identified amino acid motifs and the DNA sequences which are aberrantly expressed in the cells. By comparison of these sequences, novel antigens that are recognized by immune effector cells are identified.

La présente invention concerne des procédés d'identification d'antigènes reconnus par des cellules effectrices immunes. Dans un mode de réalisation, ces procédés combinent l'identification de motifs de séquences d'acides aminés de tels antigènes, de séquences d'ADN qui codent partiellement ces motifs, ainsi que de séquences d'ADN qui sont exprimées de manière aberrante dans les cellules. En comparant ces séquences, on peut identifier des nouveaux antigènes qui sont reconnus par des cellules effectrices immunes.

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