Antigen specific multi epitope vaccines

Details Antigen specific multi epitope vaccines Antigen specific multi epitope vaccines

C - Chemistry, Metallurgy

07

K

C07K 14/47 (2006.01) A61K 39/00 (2006.01) A61P 35/00 (2006.01) C07K 14/705 (2006.01)

Patent

CA 2665816

The present invention relates to cancer vaccines composed of the signal peptide domain of tumor associated antigens or proteins. The peptide vaccines of the invention are characterized by having multiple MHC class I and class II epitopes which are highly abundant in the population. Therefore, these vaccines are likely to induce a strong, comprehensive immune response against the target proteins in the majority of the vaccinated population, and thereby induce an immune reaction against tumors expressing such target proteins. Specifically, the invention relates to peptide vaccines composed of the signal peptide domain of Mucin (MUC1), BAGE-1 or ARMET, and their use for the treatment of cancers which express Mucin (MUC1), BAGE-1 or ARMET.

La présente invention concerne des vaccins contre le cancer composés du domaine de peptide signal d'antigènes ou de protéines associés à une tumeur. Les vaccins peptidiques de l'invention sont caractérisés par le fait qu'ils ont de multiples épitopes de classe I et de classe II du CMH qui sont très abondants dans la population. Par conséquent, ces vaccins sont susceptibles d'induire une réponse immunitaire forte et étendue contre les protéines cibles dans la majorité de la population vaccinée, et d'induire par là une réaction immunitaire contre des tumeurs exprimant de telles protéines cibles. L'invention concerne particulièrement des vaccins peptidiques composés du domaine de peptide signal de la Mucine (MUC1), BAGE-1 ou ARMET, et leur utilisation pour le traitement de cancers qui expriment la Mucine (MUC1), BAGE-1 ou ARMET.

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