Antigen specific plasmacytomas and antibodies derived therefrom

Details Antigen specific plasmacytomas and antibodies derived therefrom Antigen specific plasmacytomas and antibodies derived therefrom

C - Chemistry, Metallurgy

12

P

167/139, 195/1.1

C12P 21/08 (2006.01) A61K 39/395 (2006.01) C07K 16/00 (2006.01) C12N 15/867 (2006.01)

Patent

CA 2030933

Abstract Disclosed herein is a method for producing antibodies against an antigen of interest. Animal cells are exposed to both the antigen of interest and a recombinant retroviral vector. The vector contains a combination of oncogenes capable of inducing plasmacytomas. Plasmacytoma formation takes place rapidly and takes place in the presence of the antigen. A very high proportion of the plasmacytomas that are recovered are antigen specific.

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