Antigen targeting

Details Antigen targeting Antigen targeting

C - Chemistry, Metallurgy

07

K

C07K 16/28 (2006.01) A61K 39/00 (2006.01) A61K 39/21 (2006.01) A61K 39/385 (2006.01) A61P 37/04 (2006.01)

Patent

CA 2445537

The present invention provides a method of raising an immune response in an animal. The method comprises administering to the animal a composition comprising a carrier and an antigen bound to a targeting moiety wherein the targeting moiety binds to at least one receptor present in circulatory vessels in Gut Associated Lymphoid Tissue. It is preferred that the targeting moiety binds to Mucosal Addressin Cellular Adhesion Molecule-1.

L'invention concerne un procédé permettant d'apporter une réponse immunitaire chez un animal. Il consiste à administrer à l'animal une composition renfermant un vecteur et un antigène lié à un fragment de ciblage, ce dernier étant lié à au moins un récepteur présent dans des vaisseaux circulatoires dans le système lymphoïde du tube digestif. De préférence, le fragment de ciblage se lie à une molécule-1 d'adhérence cellulaire d'adressine de muqueuse.

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