C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
167/129, 167/139
C12N 5/18 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61K 51/10 (2006.01) C07K 7/08 (2006.01) C07K 16/00 (2006.01) C07K 16/42 (2006.01) C07K 16/46 (2006.01) C07K 19/00 (2006.01) G01N 33/554 (2006.01) G01N 33/564 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01)
Patent
CA 1340233
Unique antigenic epitopes of IgE (designated ige.b1) which are present on IgE-bearing B lymphocytes but not basophils are described. Monoclonal antibodies which bind to the epitopes are useful to treat IgE-mediated allergy. The monoclonal antibodies, either alone or as cytotoxin-conjugated immunotoxins, can be used to reduce or deplete IgE-producing B cells in allergy sufferers. The antibodies may also have the additional therapeutical effects of clearing IgE from circulaton by forming immune complexes. Monoclonal antibodies against the paratope of the antibody can be used to actively immunize allergy sufferers to attain the same results of administering the monoclonal antibody.
587431
Chang Tse-Wen
Sun Bill Nai-Chau
Sun Cecily Rou-Yun
Chang Tse-Wen
Smart & Biggar
Sun Bill Nai-Chau
Sun Cecily Rou-Yun
Tanox Inc.
LandOfFree
Antigenic epitopes of immunoglobulin e present on b cell but... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Antigenic epitopes of immunoglobulin e present on b cell but..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Antigenic epitopes of immunoglobulin e present on b cell but... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1221204