Antigenic epitopes present on membrane-bound but not...

Details Antigenic epitopes present on membrane-bound but not... Antigenic epitopes present on membrane-bound but not...

C - Chemistry, Metallurgy

07

K

C07K 16/46 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) C07K 16/00 (2006.01) C07K 16/42 (2006.01) C12N 5/18 (2006.01) C12N 15/13 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2060666

Antigenic epitopes associated with the extracellular segment of the domain which anchors immunoglobulins to the B cell membrane are disclosed. These epitopes are present on IgA-bearing B cells but not the secreted, soluble form of IgA. The ep- itopes can be exploited for therapy and prophylaxis. For example, antibodies specific for the epitopes associated with the anchor- ing peptide encompassing the epitope domain of IgA can be used to increase secretory IgA production for the purposes of treat- ing patients with infectious disesases and IgE-mediated allergic diseases.

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