Antigenic fusionprotein carrying gal.alpha.1,3gal epitopes

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/62 (2006.01) A61M 1/36 (2006.01) C07K 14/705 (2006.01) C07K 16/00 (2006.01) C07K 19/00 (2006.01) C12N 9/10 (2006.01) C12N 15/12 (2006.01) C12N 15/13 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2255765

The present invention relates to an antigenic fusionprotein, which carries multiple Gal.alpha.1,3Gal epitopes. The fusion protein according to the invention may also be comprised of a heavily glycosylated mucin part, which mediates binding to selectins, such as PSGL-1, and a part, which exhibits immunoglobulin properties, such as the Fc part of IgG. The fusionprotein according to the invention is preferably used as an absorber to prevent a hyperacute rejection of a xenotransplant, such as a pig tissue or organ transplanted into a human patient. In addition, the invention relates to a method for the prevention of a hyperacute rejection reaction in a patient who is to receive a xenotransplant.

La présente invention concerne une protéine de fusion antigénique portant de multiples épitopes Gal.alpha.1,3Gal. La protéine de fusion de l'invention peut également comprendre une partie mucine fortement glycosylée, qui induit la liaison des sélectines, telles que la PSGL-1, et une partie présentant des propriétés d'immunoglobuline, telle que la partie Fc de IgG. La protéine de fusion de l'invention est utilisée, de préférence, comme absorbeur pour empêcher le rejet suraigu d'un xénotransplant, tel qu'un tissu ou un organe porcin transplanté sur un patient humain. En outre, l'invention a pour objet un procédé destiné à prévenir une réaction de rejet suraigu chez un patient devant recevoir un xénotransplant.

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