Antigenic gm-csf peptides and antibodies to gm-csf

Details Antigenic gm-csf peptides and antibodies to gm-csf Antigenic gm-csf peptides and antibodies to gm-csf

C - Chemistry, Metallurgy

07

K

C07K 14/535 (2006.01) A61K 39/395 (2006.01) A61P 29/00 (2006.01) A61P 31/00 (2006.01) A61P 35/02 (2006.01) A61P 37/02 (2006.01) C07K 7/08 (2006.01) C07K 16/24 (2006.01) C12N 5/16 (2006.01) C12N 15/13 (2006.01) C12P 21/08 (2006.01)

Patent

CA 2641169

Hybridoma lines that secrete human monoclonal antibodies with high binding specificity and biological activity, particularly neutralizing activity against granulocyte-macrophage colony stimulating factor, and methods of generating the hybridoma lines are provided. Target antigens and epitopes are also provided. The antibodies may be used in therapeutic methods, for example in the treatment of cancer, infectious disease, or autoimmune disease.

La présente invention concernes des lignées d'hybridomes sécrétant des anticorps monoclonaux humains avec une haute spécificité de liaison et d'activité biologique, notamment une activité neutralisante contre le facteur de stimulation de colonies de granulocytes, et des procédé de génération des lignées d'hybridomes. L'invention concerne également des antigènes et des épitopes cibles. Les anticorps peuvent être utilisés dans des procédés thérapeutiques, par exemple, dans le traitement du cancer, de maladie infectieuse, et de maladie autoimmunitaire.

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