A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
167/129, 530/13
A61K 39/385 (2006.01) A61K 39/00 (2006.01) C07K 13/00 (1985.01) A61K 37/38 (1985.01) C07K 7/20 (1985.01)
Patent
CA 1264000
ANTIGENIC MODIFICATION OF POLYPEPTIDES Abstract Modified polypeptides capable of provoking the formation of antibodies in an animal may be produced by forming a linear polymer of polypeptide fragments, each having a molecular structure similar to a fragment of the protein to which antibodies are to be provoked. Such linear polymers can be made more immunogenicthan the proteins to which they are related without introducing undesirable extraneous materials into the animal being treated, but have reproducable immunogenic properties. Proteins which are not endogenous or immunogenic to an animal can be chemically modified so as to make them more immunogenic. Also, modified antigens useful for fertility control can be produced by chemical modi-fication of zona pellucida or sperm antigens. These modified polypeptides, antigens and modified antigens are desirably administered in the form of a vaccine having a vehicle comprising a mixture of mannide monooleate with Squalene and/or Squalene.
448823
Macrae & Co.
Stevens Vernon C.
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