A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/00 (2006.01) A61K 38/45 (2006.01) A61P 35/00 (2006.01) A61P 37/04 (2006.01)
Patent
CA 2336743
This invention relates to proteins or peptides which elicit T cell mediated immunity, and to cancer vaccines and compositions for anti-cancer treatment comprising such proteins or peptide fragments. This invention also relates to pharmaceutical compositions comprising the proteins or peptides and methods for generating T lymphocytes capable of recognising and destroying tumour cells in a mammal. More specifically, a telomerase protein or peptide for use in a method of treatment or prophylaxis of cancer is provided. In a preferred embodiment, the method comprises generating a T cell response against telomerase.
La présente invention concerne, d'une part des protéines ou peptides qui suscitent l'immunité à médiation des lymphocytes T, et d'autre part des vaccins anticancéreux et des compositions pour traitement anticancéreux comprenant de telles protéines ou de tels fragments de peptides. L'invention concerne également des compositions pharmaceutiques comprenant ces protéines ou peptides ainsi que les procédés permettant la production de lymphocytes T capables de reconnaître et de détruire des cellules tumorales chez un mammifère. L'invention concerne plus particulièrement une protéine télomérasique ou un peptide télomérasique destiné au traitement ou à la prophylaxie du cancer. Selon une réalisation préférée, le traitement consiste en la génération d'une réponse lymphocytaire T dirigée contre la télomérase.
Eriksen Jon Amund
Gaudernack Gustav
Gjertsen Marianne Klemp
Moller Mona
Saeboe-Larsen Stein
Fetherstonhaugh & Co.
Gemvax As
Norsk Hydro Asa
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